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Peter S Steyger, Associate Professor of
Otolaryngology, Head and Neck Surgery
Seminar: Aminoglycoside trafficking in the mammalian cochlea
Summary: Aminoglycosides are critical for treating meningitis, and
prophylaxis in severe injuries, but have serious side effects, causing
ototoxicity and nephrotoxicity.In the inner ear, aminoglycosides enter
sensory hair cells across the apical, endolymphatic membranes, including
the mechanoelectrical transduction channel in vitro. This implies that
in vivo aminoglycosides enter hair cells primarily from endolymph. This
presentation will discuss the different routes by which aminoglycosides
enter endolymph in vivo to induce cytotoxicity in sensory hair cells and
thereby induce deafness and vestibular deficits.
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