David H.
Peyton
Professor
of Chemistry
Portland State University
eMail:
peytond@pdx.edu
Other Appointments:
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Ph.D. |
1983 |
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Postdoctoral |
1983 - 1985 |
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Postdoctoral |
1985 - 1987 |
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Visiting Scholar |
2000 |
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Visiting Professor |
2004 |
What are others saying about us?
Teaching:
We will be using webCT for our classes; login from http://psuonline.pdx.edu/
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CH 436/536 |
Fall, 2006 |
Spectrometric Analysis |
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CH 437/537 |
Fall, 2006 |
Spectrometric Analysis Lab |
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CH 490 |
Fall, 2006 |
Biochemistry: Structure & Function |
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CH 471/571 |
Winter, 207 |
Biological NMR Spectroscopy |
Research:
Medicinal Chemistry
Biophysical
Chemistry
The main research theme in
the Peyton research group is the study of the relation of structure to function
in biological molecules by application of nuclear magnetic resonance
spectroscopy. However, other tools may be used, depending on the nature of a
particular problem. These tools include organic synthesis, electronic
spectroscopy, and computer modeling/dynamics.
The following is a
‘gallery’ of some of the specific projects that are currently being
investigated. Some of these projects are fairly mature, while others are just
getting started.
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Reversed Chloroquines as Antimalarial Agents |
Chloroquine (CQ) is one of the safest and most
effective drugs ever developed, but resistance has emerged against it. We
have developed a way to modify CQ to circumvent this problem. |
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Antimalarial drug design: This is being done in
collaboration with Michael
Riscoe, of the Portland VA
Hospital. |
Xanthones bind to heme,
making them potential agents against parasites causing diseases, including
malaria and leishmaniasis. |
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Collagen This is being done in
collaboration with Hans Peter
Bächinger, of the Portland
Shriners Hospital. |
After so many years as a
textbook case, we still don’t really know the canonical reasons for the
stability of collagen, our most abundant protein. We are particularly
interested in glycosylated collagens, lacking hydroxyproline. |
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Nicotine in cigarette smoke This is being done in
collabaration with Jim Pankow,
of the Oregon Graduate Institute/OH&SU. |
The amount and the
protonation state of nicotine in cigarette smoke are key factors in both
traditional and ‘reduced harm’ cigarettes. NMR provides a way to assess these
quantities. |
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Selected
& Recent Publications:
Tobacco smoke particulate matter chemistry by NMR
Barsanti K.C., Luo W., Isabelle L.M., Pankow J.F., Peyton D.H. (2007) Magn.
Reson. Chem. 459, 167-170
A Chloroquine-like Molecule Designed to Reverse Resistance
in Plasmodium falciparum
Burgess, S. J.; Selzer, A.; Kelly, J. X.; Smilkstein, M. J.; Riscoe, M. K.;
Peyton, D. H. (2006) J. Med. Chem. 49, 5623-5625
The Peptides Acetyl-(Gly-3(S)Hyp-4(R)Hyp)10-NH2
and Acetyl-(Gly-Pro-3(S)Hyp))10-NH2 do not form a
Collagen Triple Helix
K. Mizuno, T, Hayashi, D.H. Peyton, & H.P Bächinger (2004) J. Biol. Chem.,
279, 282-287
The role of carbohydrate in stabilizing the
triple-helix in a model for a deep-sea hydrothermal vent worm collagen
J.G. Bann, H.P. Bächinger, & D.H. Peyton (2003) Biochemistry, 42, 4042-4048
Fraction of Free-Base Nicotine in Fresh Smoke
Particular Matter from the Eclipse “Cigarette” by 1H NMR
Spectroscopy
J.F. Pankow, K.C Barsanti, & D.H. Peyton (2003) Chem. Res. Toxicol., 16,
23-27
Antileishmanial Drug Development:
Exploitation of Parasite Heme Dependency
J.X. Kelly, M.V. Ignatuschenko, R.W. Winter, H.G. Bouwer, D.H. Peyton, D.J.
Hinrichs, & M. Riscoe (2003) Mol. Biochem. Parasitol., 126, 43-49
A Circularly Permuted Myoglobin Possesses a
Folded Structure and Ligand Binding Similar to Wild-type Protein but with
Reduced Thermodynamic Stability
A.L. Fishburn, J.R. Keeffe, A.V. Lissounov, D.H. Peyton, & S.J.
Anthony-Cahill (2002) Biochemistry, 41, 13318-13327
The Kinetics of Uptake and Accumulation of
3,6-w-diethylaminoamyloxyxanthone by the Human Malaria parasite Plasmodium
falciparum
J.X. Kelly, R.W. Winter, A. Cornea, D.H. Peyton, D.J. Hinrichs, & M. Riscoe
(2002) Mol. Biochem. Parasitol., 123, 47-54
Optimization of Xanthones for Antimalarial
Activity, the 3,6-w-diethylaminoalkoxyxanthone Series
J.X. Kelly, R. Winter, D.H. Peyton, D.J. Hinrichs, & M.K. Riscoe (2002)
Antimicrob. Agts. Chemo., 46, 144-150
Antileishmanial Drug Development:
Exploitation of Parasite Heme Dependency
J.X. Kelly, M.V. Ignatuschchenko, R.W. Winter, H.G. Bouwer, D.H. Peyton, D.J.
Hinrichs, & M. Riscoe (2002) Mol. Biochem. Parasitol., 123, 47-54